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Antiphospholipid Syndrome and Other Thrombophilia Disorders

Thrombophilia disorders such as antiphospholipid syndrome and Factor V Leiden are among the few recognized risk factors and potential causes of recurrent miscarriages. Learn about the diagnosis and treatment of thrombophilia disorders in the context of pregnancy loss.
Hughes Syndrome - Experiences with Hughes Syndrome (Antiphospholipid …
Have you had Hughes syndrome (antiphospholipid syndrome) during pregnancy? Was the condition diagnosed after a history of miscarriages? Share your story here.
Homocysteine and Miscarriage - What You Should Know
Homocysteine can be elevated in people with MTHFR gene variants or deficiency of folic acid and B vitamins, and some research has found a link between high-homocysteine levels and risk of miscarriage or recurrent miscarriages. Find out more about the association.
Factor V Leiden and Recurrent Miscarriages
Factor V Leiden is a genetic variant in the factor V clotting protein. Having the Factor V Leiden gene increases the risk of miscarriage and deep vein thrombosis. Some doctors recommend heparin for women with recurrent miscarriages who test positive for Factor V Leiden.
MTHFR and Recurrent Miscarriages - What's the Story?
MTHFR gene mutations can increase the risk of high homocysteine and might increase the risk of blood clots. Some doctors test for and treat common MTHFR gene variants as a risk factor for recurrent miscarriages, while others consider MTHFR tests worthless in treating miscarriages. What gives?
Antiphospholipid Antibody Syndrome and Recurrent Miscarriages
Antiphospholipid antibodies may cause recurrent miscarriages in some women, but are rarely associated with any symptoms before that. The most common antibodies tested are lupus anticoagulant antibodies and anticardiolipin antibodies. Treatment with heparin and low-dose aspirin may improve pregnancy outcomes for women with recurrent miscarriages.
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  5. Two or More Miscarriages
  6. Thrombophilia Disorders

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